Neurotropic Viruses: An insight into their movement
The rabies virus moves differently compared to other neuron-invading viruses and its journey can be blocked by a drug commonly used to treat amoebic dysentery. It is when the immune system is compromised that most viruses infect the nervous system accidentally. But there are certain viruses called the neurotropic viruses that target neurons as part of their normal infectious cycle . The rabies virus is an example to this where the virus is transmitted when an infected animal bites a host. It then spreads into the end terminals of motor neurons innervating the muscle and travels along the neurons' long axon fibres to the neuronal cell bodies, throughout the central nervous system and into the salivary glands, where it can be transmitted to other hosts. Alpha herpes viruses, such as herpes simplex viruses, also enter peripheral nerve terminals and move along axons to the neuronal cell body, where they can lie dormant. Alpha Herpes viruses engage the neuronal transport mac...