A revolutionary approach into the developement of vaccine to prevent AIDS from mother to babies

"Finding out what protects the majority of babies is very important, because it will cause ways that to spice up natural immune responses and build people proof against HIV infection, aforesaid Peter Kessler, laboratory intern with the Emory University faculty of drugs. Scientists had been speculative for years by the actual fact that solely a minority of babies born to mothers with HIV infection get the infection from their mothers. Currently, HIV infection is with success managed with antiretroviral medicine, however these medicine need to incline for all times. Preventing the infection is incredibly vital, however there's no immunizing agent on the market.
However, Kessler and his colleagues found that levels of Treg lymphocytes were higher within the blood of new born babies born to mothers with HIV infection. World Health Organization had at large the infection themselves, compared with babies World Health Organization were born with HIV infection.
 
Lymphocytes are cells of the system that shield the body by fighting microorganism and viruses. Treg cells also called regulative T cells, help to forestall excessive immune reactions that would cause tissue harm.
The researchers examined the blood of sixty four babies World Health Organization were born HIV-uninfected and twenty eight babies born HIV-infected and located that Treg cell levels were higher in antiseptic babies at the time of birth. In distinction, different WBC sorts were activated and better in HIV-infected infants. The HIV virus will solely infect cells that are activated, therefore Treg might shield from HIV infection by suppressing activation of different lymphocytes.
They analyzed the blood by flow cytometry, a way that may differentiate between the various sorts of cells supported what markers they specific on their surface. regulative T cells are available in several forms with the foremost well-understood being people who specific the markers CD4, CD25, and FOXP3.
these findings indicate that Treg, by dominant immune activation, might lower the vulnerability of the babies to HIV or different chronic infections even before they're born," aforesaid Kessler. These results might pave the method for the event of vaccines or different immune-based therapies that would be used at the side of medications to forestall the unfold of HIV or different infections from mothers to their babies.

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