Garlic Bulbs: Inhibits bacterial growth?


The study is the first to show that the chemical -- known as allicin -- could be an effective treatment against a group of infectious bacteria that is highly resistant to most antibiotics.
Allicin is a natural compound secreted by garlic bulbs. This chemical compound ward off a closely-related group of plant pathogens found in soil and water habitats.
In the 1980s, a bacteria -- known as the Burkholderia cepacia complex (Bcc) -- emerged as a cause of serious and transmissible lung infections in people with cystic fibrosis.
 The Bcc are highly versatile plant and human pathogens that have not been studied to the same extent as other superbugs -- such as MRSA. The bacteria produce potent antimicrobial agents, making them naturally drug-resistant and allowing them to survive in polluted and antibiotic-rich environments.
Caution Measures to limit the spread of Bcc infections among people with cystic fibrosis brought the number of cases down considerably. However, current therapies available to treat infections -- that are potentially fatal -- are limited and require the use of combinations of three to four antibiotics at a time.
It had now been found that allicin -- which can be extracted by crushing raw garlic -- inhibits the growth of bacteria and, at higher doses, kills the plant pathogens. The team suggests that allicin kills Bcc bacteria by chemically modifying key enzymes. This deactivates them and halts important biological processes within the pathogens' cells.
allicin-containing remedies could be used in allicin kills the bacteria combination with existing antibiotics to treat Bcc infections. However, the mechanisms by which allicin kills the bacterium has to be well understood before the chemical can be incorporated into new treatments.
At a time when novel antimicrobial agents are urgently required, chemical and microbiological research has the potential to unlock the rich reservoir of antimicrobial compounds present in plants such as garlic. Allicin-containing compounds merit further investigation as adjuncts to existing treatments for infections caused by Bcc."
"The medicinal power of garlic has a rich history that dates back thousands of years but the chemical structure of allicin was only revealed in the 1940s. This work suggests that modern methods should be used to further expand our knowledge of this enigmatic molecule and rejuvenate its potential applications."


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