Meningococcal bacterial aggregates form a thick honey-like liquid that flows through blood vessels

A key stage in infection by Neisseria meningitis, a human pathogen to be blamed for meningitis in infants and young adults was unravelled by a group of scientists at the Pasteur Institute. The progression of the infection was facilitated and aggravated by the blood aggregates formed in the blood vessel. Though treatment is run quickly, the death rate due to meningococcal infections remains terribly high.
Human meningococcal infectious disease is characterised by the accumulation of bacteria in blood vessels, that fully top off with bacterium. However the mechanisms that govern the formation of those aggregates and also the impact of the process is still unknown. A syndicate of scientists, intrigued by this formation of intravascular aggregates, started to know this stage of infection, particularly its underlying physical basis. Their findings discovered that "the microorganism aggregates fashioned by Neisseria meningitidis appeared to be a thick liquid, like that of honey. Analysis shows that the formation of those aggregates and their viscous properties are important for the progression of the infection. A microorganism mutant that forms solid instead of liquid aggregates is at a substantial disadvantage in colonizing blood vessels.
The thick liquid nature of the aggregates depends on a virulence issue referred to as type IV pili. These long filaments, that have adhesive and dynamic properties, are perpetually extending and retracting at the microorganism surface. The bacterium use type IV pili to search out different bacterium, draw them in and briefly establish contact. Thus Aggregation takes place as a result of intermittent method of attraction between bacteria; in different words a relentless alternation between the presence and absence of attraction. As well as rising our understanding of a deadly human infection, our analysis reveals a brand new kind of active matter -- a microorganism combination with a viscous, honey-like consistency -- supported the intermittent engaging forces between its element elements This multidisciplinary study was the results of shut collaboration between a laboratory specializing in meningococcal infections and physicists. 

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